Description
The Immune Epitope Database (IEDB) contains data related to antibody and T cell epitopes for humans, non-human primates, rodents, and other animal species. Curation of peptidic and non-peptidic epitope data relating to all infectious diseases (including NIAID Category A, B, and C priority pathogens and NIAID Emerging and Re-emerging infectious diseases), allergens, autoimmune diseases, and transplant/alloantigens is current and constantly being updated.
The columns in the netMHC output are: position in the sequence, peptide used for prediction, logscore, affinity in nM, binding level (weak/strong binding or NA), the accession of the peptide in the database and the HLA allele.
For questions on IEDB please contact [email protected].
Methods
Data was downloaded from IEDB. Epitope linear protein sequences were mapped to UniProt reference sequences with BLAST and from there to the genome with BLAT with pslMap. The program netMHC was run to predict the most likely HLA type for all peptides with a length 8-11 amino acids.
References
Vita R, Zarebski L, Greenbaum JA, Emami H, Hoof I, Salimi N, Damle R, Sette A, Peters B. The immune epitope database 2.0. Nucleic Acids Res. 2010 Jan;38(Database issue):D854-62. Epub 2009 Nov 11.
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US Server